New Science

A new study proves that a combination of MFAT and PRP provides effective medium-long-term joint protection and relief from symptoms in people with knee osteoarthritis. In this study, the authors prepared micro-fragmented adipose tissue (MFAT) obtained from liposuction and processing using an ACP filter system and combined this with a fully characterized leucocyte-poor platelet-rich plasma (PrP) -produced using the centrifuge.The conducted clinical trial of 12 individuals with early-moderate knee osteoarthritis, examining 6-month outcomes following ultrasound-guided intraarticular injection of 7mls of the mixture (2ml, MFAT + 5ml PrP).All patients showed a significant improvement through reduced pain scoring and improvement in function and quality of life- both at rest and during movement or exercise. Contrast-enhanced MRI indicated no further degradation of the joint matrix over the period of the study. Therefore, this combination of MFAT and PrP provides a minimally invasive orthobiological approach for effective medium-long-term joint protection and abrogation of symptoms in people with knee osteoarthritis.Read more here. Make an Enquiry

A new study was published that evaluated the effectiveness of using microfragmented adipose tissue (mFAT) in combination with arthroscopic debridement (AD) for the treatment of knee osteoarthritis (OA) compared to AD treatment alone. The study involved 78 patients affected by knee OA grade 3–4 (according to KL classification), who were randomly assigned to AD or AD+mFAT treatment groups. The results of the study showed on MRI scans that AD+mFAT improved functional outcomes more than patients treated with only AD both at 6-month and 24-month follow-ups. The study’s unblinded design suggests that further evidence would be profitable to draw definitive conclusions about mFAT’s efficacy in treating knee OA, but the current results are extremely encouraging.In conclusion, the use of mFAT in combination with AD can be an effective treatment option for knee OA, providing durable effects and better outcomes compared to AD alone.Read more here. Make an Enquiry

Introduction Reports have concluded that platelet-rich plasma (PRP) is an effective and safe biological approach to treating knee osteoarthritis (OA). However, the…

Dr Konrad Slynarski is an internationally recognised orthopaedic specialist and pioneer in using cell and biological therapies for bone and skeletal…

In recent years, there has been a growing interest in biologic approaches for tissue healing in various musculoskeletal (MSK) conditions and pathologies, resulting in the emergence of the field of Orthobiologics. This interest has been reflected in the significant surge in research in the MSK medicine field, with numerous pre-clinical studies demonstrating promising evidence from a considerable number of basic science pre-clinical studies, which also translated to promising results in clinical studies.Orthobiologics offer diverse non-operative solutions and can also be used in conjunction with surgical approaches. Platelet Rich Plasma (PRP) products and cell-based therapies (also known as “stem cell therapy”) have been the primary biologic products that have garnered the most attention.The increasing demand from patients to explore non-surgical options before resorting to invasive treatments, coupled with the industry’s investment in accommodating these needs, has heightened interest in orthobiologics. Orthobiologic products have shown potential in regenerating damaged cells and tissues, as well as regulating degenerative processes, and have been effective in improving function and reducing pain in various musculoskeletal (MSK) conditions. This has led to a surge in the use of orthobiologic treatments worldwide that appears to be continuously growing.However, the clinical use of biologic therapies has exceeded the available evidence and supportive research, leading to a surplus of information and misinformation. Some clinicians lack sufficient education, experience, and training in this field, with much of the available information provided by the industry. That is why here at The Regenerative Clinic, we only work with those consultants responsible for teaching other clinicians around the world. We stick with the bests.The ESSKA Orthobologics Initiative (ORBIT) initiative aims to investigate the detailed mechanisms of action of different orthobiologics in pre-clinical models to determine their potential disease-modifying effects. By conducting systematic reviews on the various available orthobiologic products in OA, the initiative’s first study analysed the disease-modifying effects of PRP for knee OA. This review included 44 studies involving over 1200 animals, which showed that PRP injections had clinical effects in 80% of the studies and disease-modifying effects in 68% of the studies. Here at The Regenerative Clinic, our patient success rate is 86% based on data pulled from over 3,000 patients. Full Article If you or someone you know is experiencing joint pain, we can help!We offer a range of orthobiolocigal treatments that use a person’s own harvested cells.Treatments include:MFAT – Micro-fragmented fat – Adipose Tissue therapy and treatment: a pioneering new treatment for pain and inflammation is a new minimally invasive treatment that harnesses natural repair cells removed from your own body fat to target problems affecting the tendons, ligaments, joints and muscles, including osteoarthritis.BMAC – Bone Marrow Aspirate Concentrate (BMAC) is a non-surgical, minimally invasive, regenerative treatment that harnesses the natural ability to heal the body through the assistance of biological growth factors. BMAC utilises the regenerative mesenchymal stem cells collected from bone marrow to aid in the acceleration of healing moderate to severe osteoarthritis and tendon injuries.PRP – Platelet Rich Plasma (PRP) therapy is also known as Autologous Conditioned Plasma. PRP takes advantage of your blood’s natural healing properties to repair damaged cartilage, tendons, ligaments, muscle and bone. It can reduce pain, improve joint function and help you return quickly to normal activities.nSTRIDE – The treatment is designed to be a single injection therapy in the outpatient clinic setting. Blood is withdrawn like a simple blood test, the clinician processes the patient’s blood to concentrate white blood cells, platelets, and plasma proteins into a small volume of plasma. Make an Enquiry

A microfragmented adipose tissue injection to the shoulder or knee of osteoarthritis patients offers a safe and effective treatment in moderate-to-severe disease, with reduced efficacy at increased BMIs.Swelling and pain in the joints is common and found more often in older and overweight people. Osteoarthritis causes swelling and pain in joints because of a loss of tough, flexible tissue called cartilage. This study looks to see if injection of fat tissue into knee or shoulder joints can improve symptoms. The fat tissue used was called microfragmented adipose tissue (MFAT). This uses a technique to break down the fat tissue before injection. These cells were from the patient’s own body.All patients had an injection of MFAT into their painful joints. In total, 59 patients took part. Reports were directly collected from the patient of how well they were doing. This was done before and after the injection at weeks 2, 6, 12, 24 and 52. There were three different types of report collected for knee joints and three for shoulder joints. Scores were then compared from these reports to see if there was a difference.An improvement was found in all three of the combined reports for both knees and shoulders. This stayed until 52 weeks. BMI is a measure of body weight in relation to height. Patients with a higher BMI were found to have had a smaller improvement in their scores.This study shows MFAT injections are safe and effective in treating painful joints.Click here to read more. If you or someone you know is experiencing joint pain, we can help!We offer a range of orthobiolocigal treatments that use a person’s own harvested cells.Treatments include:MFAT – Micro-fragmented fat – Adipose Tissue therapy and treatment: a pioneering new treatment for pain and inflammation is a new minimally invasive treatment that harnesses natural repair cells removed from your own body fat to target problems affecting the tendons, ligaments, joints and muscles, including osteoarthritis.BMAC – Bone Marrow Aspirate Concentrate (BMAC) is a non-surgical, minimally invasive, regenerative treatment that harnesses the natural ability to heal the body through the assistance of biological growth factors. BMAC utilises the regenerative mesenchymal stem cells collected from bone marrow to aid in the acceleration of healing moderate to severe osteoarthritis and tendon injuries.PRP – Platelet Rich Plasma (PRP) therapy is also known as Autologous Conditioned Plasma. PRP takes advantage of your blood’s natural healing properties to repair damaged cartilage, tendons, ligaments, muscle and bone. It can reduce pain, improve joint function and help you return quickly to normal activities.nSTRIDE – The treatment is designed to be a single injection therapy in the outpatient clinic setting. Blood is withdrawn like a simple blood test, the clinician processes the patient’s blood to concentrate white blood cells, platelets, and plasma proteins into a small volume of plasma. Make an Enquiry

New research into the largest number of studies on the effects of Orthobiologics shows that on average 70% of people who underwent Orthobiologic treatments had a favourable result. The outcomes overall show significant improvements like less pain and more mobility in over 70% of treated individuals.The analysis was conducted by Professor Mark Slevin, Professor of Cell Pathology at Manchester Metropolitan University. Professor Slevin analysed eighteen separate peer-reviewed and published global studies. Professor Slevin said, “There is a growing body of scientific evidence that is cementing the case of Orthobiologic treatments, especially for osteoarthritis and musculoskeletal (MSK) trauma, injury and degeneration. We are looking at the start of potentially an entirely new pathway of treatment that will enhance natural healing using the body’s own tissue and delay the need for more serious surgical intervention. We stand at the beginning of a huge new movement and for the very first time we now have a body of scientific evidence to prove the potential of these treatments.”Professor Slevin continues, “We note that although overall success globally is 70% the rate of success measured at The Regenerative Clinic, London is 84% successful for all procedures combined.” Read more Orthobiologic treatments use a person’s own cells which are harvested, processed by clinicians, and then using ultrasound-guided injection, inserted into the problem area.Treatments include:MFAT – Micro-fragmented fat – Adipose Tissue therapy and treatment: a pioneering new treatment for pain and inflammation is a new minimally invasive treatment that harnesses natural repair cells removed from your own body fat to target problems affecting the tendons, ligaments, joints and muscles, including osteoarthritis.BMAC – Bone Marrow Aspirate Concentrate (BMAC) is a non-surgical, minimally invasive, regenerative treatment that harnesses the natural ability to heal the body through the assistance of biological growth factors. BMAC utilises the regenerative mesenchymal stem cells collected from bone marrow to aid in the acceleration of healing moderate to severe osteoarthritis and tendon injuries.PRP – Platelet Rich Plasma (PRP) therapy is also known as Autologous Conditioned Plasma. PRP takes advantage of your blood’s natural healing properties to repair damaged cartilage, tendons, ligaments, muscle and bone. It can reduce pain, improve joint function and help you return quickly to normal activities.nSTRIDE – The treatment is designed to be a single injection therapy in the outpatient clinic setting. Blood is withdrawn like a simple blood test, the clinician processes the patient’s blood to concentrate white blood cells, platelets, and plasma proteins into a small volume of plasma. Make an Enquiry

Many people suffer from chronic tendon pain that affects daily activities, often caused by continued trauma or over usage of joints…

  Examining Timeliness of Total Knee Replacement Among Patients with Knee Osteoarthritis in the U.S.: Results from the OAI and MOST Longitudinal CohortsH M K Ghomrawi, A I Mushlin, R Kang, S Banerjee, J A Singh, L Sharma, C Flink, M Nevitt, T Neogi, D L Riddle. J Bone Joint Surg Am. 2020 Mar 18;102(6):468-476. doi: 10.2106/JBJS.19.00432. In this Meta-analysis of two large multicenter cohort studies, 3,417 knees from 2313 patients with osteoarthritis (OA) were divided using a sixteen combination algorithm (including WOMAC pain and physical function, and Kellgren Lawrence grading) to determine their ‘appropriateness’ to undergo surgical intervention with total knee arthroplasty (TKA). They were followed up for a total of 8 years. The main aim was to identify the timeliness of surgical procedures and determine if the appropriate standards of patient healthcare are being met. The results showed that of 1,114 knee replacements carried out in the two-year study period, 26.4% were considered in this classification as ‘premature’ that is, that they were carried out on individuals where alternative/biological intervention would have been more suitable. Of the 3,123 knees classified as appropriate for TKA, 2,833 were NOT replaced (90%). Although this study may not be representative of treatment in every location, there is no National longitudinal data available for comparison, so this remains the most accurate estimation for statistical evaluation. This data indicates that currently, patients may not be receiving the appropriate advice and highest level of personalized healthcare in the field of orthopedics.    Professor Mark Slevin PhD2, FRCPath, FAHAScientific Director of CCAMF – [Centru Avansat de Cercetari Medicale si Farmaceutice] Universitatea de Medicina, Farmacie, Stiinte se Technologie; “George Emil Palade” din Targu-Mures, Romania and Professor of Cell Pathology- Manchester Metropolitan University

Arthrosamid® was created by Contura International Ltd (international manufacturers of therapeutic hydrogels) and fulfils an unmet clinical need for an effective,…

Advanced osteoarthritis presents itself as the most severe form of osteoarthritis one could be diagnosed with. As a progressive condition, which…